AstraZeneca Pharmaceuticals LP Post Doc Fellow - Regulation of RNA metabolism in lung epithelium by HuR in Gothenburg, Sweden

Postdoctoral Long Title:

Demonstrating different cytoplasmic vs nuclear roles of the mRNA stabilizing protein HuR in the lung epithelium stress response using blocking intrabodies

We’re currently looking for talented scientists to join our innovative academic-style Postdoc. From our centre in Gothenburg, SE, you’ll be in a global pharmaceutical environment, contributing to live projects right from the start. You’ll take part in a comprehensive training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research in cutting edge laboratories. It’s a newly expanding programme spanning a range of therapeutic areas across a wide range of disciplines.

What’s more, you’ll have the support of a leading academic advisor, who’ll provide you with the guidance and knowledge you need to develop your career. This is an exciting area that hasn’t been explored to its full potential, making this an opportunity to make a real difference to the future of medical science.

About AstraZeneca

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energised and rewarded for their ideas and creativity.

Our Respiratory, Inflammation and Autoimmunity team offers definitive expertise to colleagues across the business. You’ll help respiratory patients in areas with medical needs that aren’t being fully met, including chronic obstructive pulmonary disease and asthma and rheumatic disorders tackling these diseases from three areas lung immunity, lung epithelium, and lung remodelling/regeneration. Right now, We are a leading figure in inhaled drug development, and our new Inhalation Centre in Gothenburg, Sweden coupled with our work in new modalities is set to extend that lead even further.

A Postdoctoral position is available at Respiratory, Inflammation and Autoimmunity Innovative Medicines Unit, AstraZeneca R&D, Gothenburg, Sweden, in the Lung Epithelium department. The successful candidate will work in a cross-disciplinary research team that integrates basic, translational and clinical science, with epithelial barrier function and epithelial senescence as key focus areas. This project will employ a broad range of molecular and cellular biological methods to understand different levels of RNA regulation occurring in response to environmental stress associated with respiratory diseases. The selected candidate will have access to state-of-the-art capabilities and new modalities to target specific RNA-protein interactions, the project offers a unique opportunity to establish RNA metabolism as a novel target landscape in respiratory diseases.

Accountabilities and Responsibilities:

  • Master a range of experimental techniques and methods including, but not limited to: mammalian cell culture, cell transfection and transduction, qPCR, ELISA, western blotting, and functional cell assays relevant for lung epithelium

  • Drive and perform studies of RNA regulation in lung epithelial cell culture systems

  • Design and carry out genome-wide studies of protein-RNA interactions

  • Plan, write, and publish high quality publications

  • Contribute to external and internal scientific visibility through poster & oral presentations

Education and Experience Requirements:

Essential:

  • PhD in a relevant area, post-doctoral experience is a plus

  • Advanced proficiency in standard biochemical, molecular and cell-based techniques

  • Experience of working with primary cell cultures

  • Experience in studies of RNA processing and regulation

  • Proficiency in the biochemistry of protein-RNA complexes

  • Experience in genome-wide studies of protein-RNA interactions

Desirable:

  • Knowledge of lung biology and respiratory diseases

  • Experience of working with epithelial cells

  • Experience in computational analysis of genomic data (programming with R)

  • Several examples of previous work published in peer-reviewed journals

Skills and Capabilities required:

  • Innovative problem solver

  • Ability to work in a cross-disciplinary team environment

  • Proven ability to produce publications

  • Good communication skills at a variety of levels

  • Excellent written and spoken English

This is a 3 year programme. 2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based. The role will be based at Gothenburg, SE with a competitive salary on offer

To apply for this position, please click the apply link below.

Advert opening date – 5th March 2018

Advert closing date – 14th May 2018

AstraZeneca welcomes applications from all sections of the community.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

If you share our passion for scientific excellence, find out more at; https://careers.astrazeneca.com/students/programmes/post-doctoral-programmes