AstraZeneca Pharmaceuticals LP Post Doc Fellow - Photoredox catalysis in medicinal chemistry in Gothenburg, Sweden
Postdoctoral Long Title:
Development of new photoredox-catalysed reactions for the synthesis of unnatural amino acids
We are currently looking for talented scientists to join our innovative academic-style Postdoc. From our centre in Gothenburg, you will be in a global pharmaceutical environment, contributing to live projects right from the start. You will take part in a comprehensive training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research in cutting edge laboratories. It’s a newly expanding programme spanning a range of therapeutic areas across a wide range of disciplines.
What’s more, you will have the support of a leading academic advisor, who will provide you with the guidance and knowledge you need to develop your career. This is an exciting area that has not been explored to its full potential, making this an opportunity to make a real difference to the future of medical science.
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energised and rewarded for their ideas and creativity.
As a world leader in cardiovascular, renal and metabolic medicines, we’re always working on innovative new drugs that will change lives across the globe. To make that happen, we employ a small molecule and new modalities research and development strategy with three priorities: heart failure, diabetes and chronic kidney disease. You’ll focus your efforts on making real progress toward slowing, stopping or curing some of the most aggressive diseases that face humanity today.
C–H bond activation followed by carbon-carbon bond formation is one of the most promising and powerful method for the synthesis of organic compounds. In the current role, you will develop photoredox/transition metal catalysed systems that can effect carbon-carbon bonds in nitrogen-containing compounds, and using carbon dioxide as one-carbon building-block. You will be guided and coached by scientists at AstraZeneca. In addition, you will have the opportunity to collaborate and be mentored by Professor Burkhard König, at the University of Regensburg, Germany (http://www-oc.chemie.uni-regensburg.de/koenig/). Moreover, you will have access to state-of-the-art equipment and facilities that will allow you to develop novel methodologies using high-throughput experimental methods and in flow.
Accountabilities and Responsibilities:
Along with discovering photoredox systems that can promote novel bond-forming reactions, you will inspire and influence internal and external chemists through interactions with internal project teams, external conference presentations, and publication in peer-reviewed journals. You will benefit from being exposed to a vibrant, multicultural, and collaborative environment and to colleagues with a wide range of research expertise. You will apply your discovery to the late-stage functionalisation (LSF) of advanced medicinal chemistry intermediates.
Education and Experience Required:
PhD in synthetic organic chemistry with an emphasis on synthetic method development
An outstanding track record of research, proven by high impact publications in peer reviewed journals, patents and/or talks at scientific meetings
Solid background in organic chemistry with focus on catalysis and in particular transition-metal catalysis
Excellent oral and written communication skills
Demonstrated success across a broad range of synthetic challenges
Strong working knowledge of the mechanistic principles of photoredox and transition-metal chemistry
In-depth knowledge of late-stage functionalisation reactions, focusing on C–H activation catalysis
Strong knowledge and working experience with common analytical techniques in a synthetic organic chemistry laboratory, including NMR, HPLC, GC and MS
Strong organisational, communication and interpersonal skills
Strong passion and commitment towards science
Knowledge of photoredox-mediated synthetic methodology
Knowledge of high-throughput or parallel chemistry approaches towards novel reaction discovery and optimisation
Skills and Capabilities required:
Independently design and execute experiments and interpret results
Work towards defined goals in an efficient, safe and scientifically sound manner
Generate and test new hypothesis
Willingly share expertise and ideas, demonstrate flexibility and open-mindedness
Present results at scientific conferences and publish scientific papers in high quality, peer-reviewed journals
Analytical thinker and critical problem solver
This is a 3 year programme. 2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based. The role will be based at AstraZeneca Gothenburg with a competitive salary on offer
To apply for this position, please click the apply link below.
Advert opening date – 5th March 2018
Advert closing date – 13th May 2018
AstraZeneca welcomes applications from all sections of the community.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.
If you share our passion for scientific excellence, find out more at; https://careers.astrazeneca.com/students/programmes/post-doctoral-programmes