AstraZeneca Pharmaceuticals LP Senior Scientist - Mechanistic Biology & Profiling - Discovery Sciences in Gothenburg, Sweden
Placement: Gothenburg, Sweden
At AstraZeneca we win through science, it’s at the heart of our every success. That science is only possible when we all work together – we’ll always make sure you’re clear about how your role is connected to our wider mission to really show what science can do.
An exciting opportunity has arisen for a highly motivated Senior Scientist to join the Mechanistic Biology & Profiling Department within the Discovery Sciences Innovative Medicine (IMED) in Gothenburg, Sweden.
Leading from the bench, you will apply proven cell biology expertise and a passion for driving scientific questions, combined with strong team working ethics, to drug discovery projects. You will join one of the Molecular Screening and Profiling teams whose remit is to support IMED projects globally with delivery of screening and mechanism of action data for project compounds.
Main Duties and Responsibilities
This is a lab-based role, providing in vitro target-based and phenotypic screening to support projects in all phases of the discovery process. The role involves proposing experimental strategies, troubleshooting and making a significant contribution to the practical delivery of projects as well as novel science to advance our capability and for external presentation.
Candidates should have a Ph.D. or a first degree and at least 4 years’ experience within a relevant scientific discipline
Expertise in cell-based screening of a variety of mammalian cell types (including primary, iPS and immortalized cell lines)
Theoretical understanding of assay design relevant to the pharmacology of the drug target and a practical understanding of assay optimisation and use of statistical tools to enable generation of robust, reproducible and sensitive assays
Practical knowledge of detection technologies and technology platforms compatible with cellular assays, including ideally flow cytometry and imaging
Data analysis and conversion of screening data to biological parameters
Experience in design and execution of complex pharmacology studies to understand compound mechanism of action
Excellent communication skills and an ability to operate effectively in a multi-disciplinary research environment
Independent analysis and evaluation of complex data and delivery of data to agreed timelines
Provide technical leadership and guidance to others
Maintain an awareness of relevant scientific and technical advances to help identify opportunities for capability development
Scientific visibility and leadership through project contributions, internal presentations and external publications.
Excellent problem solving skills, not limited to own area of expertise
First rate decision making skills, coupled with tenacity to see decisions through, even in situations of ambiguity
Track-record in publishing scientific manuscripts in peer-reviewed journals, and presenting at external conferences
Recognized scientific expertise within the area of cell biology as applied to screening and will function as a scientific expert within project teams.
Good understanding of drug discovery and how to translate their scientific expertise into new project and business opportunities.
Global Career level: D
If you are interested, apply now!
For more information about the position please contact: Per-Erik Strömstedt at +46 31 7762010.
Welcome with your application no later than 14 July, 2017
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.